As side effects, agitation was noted after the use of flumazenil, and a decrease in the prothrombin time during infusion of N-acetylcysteine. In three cases there was no indication for administration: flumazenil without respiratory depression, and vitamin K following coumarin exposure. Sixty-seven patients received an antidote (3.9% of consultations for suspicious poisoning), and a total of 69 administrations of an antidote were made: 100% oxygen (46), N-acetylcysteine (10), flumazenil (4), naloxone (3), deferoxamine (2), vitamin K (2), bicarbonate (1), and carnitine (1). In 353 cases (20.4%) the involved poison could be treated with an antidote. ResultsĪ total of 1728 consultations for suspicious poisoning (0.4% of the total visits in the PED) were recorded. The adequacy of antidote indication was based on the recommendations of the Spanish Society of Paediatric Emergencies (SSPE). Inclusion criteria were age younger than 18 years and consultation for suspicious poisoning by a substance that could be treated with an antidote. Materials and methodsĪ retrospective review of antidote use in a PED between January 2008 and June 2012. To analyse the use of antidotes in a PED and to assess the suitability of their indications. Paediatricians should know how to use the available antidotes properly. Poisoning is an infrequent cause of consultation in a paediatric emergency department (PED), but it can be potentially serious.
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